This is the best summary I could come up with:

“We want to do something to help those who are suffering from tooth loss or absence,” lead researcher Katsu Takahashi told Japanese newspaper The Mainichi.

“While there has been no treatment to date providing a permanent cure, we feel that people’s expectations for tooth growth are high.”

In 2021, his team discovered a gene – uterine sensitization-associated gene-1 (USAG-1) – that appeared to stop the production of additional teeth in mice.

Deactivating that same gene and stopping production of the protein it regulates has also caused other animals to grow lost, or even additional, teeth.

Takahashi and his team have spun up their own company called Toregem Biopharma to commercialize the USAG-1 drug, and hope to have it on the market by 2030.

While initial tests are mainly focused on congenital tooth loss, the team hopes teeth lost due to cavities, injury, and other accidents will be regrowable as well.

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