I used to use FL Studio, but hated using Windows. I got almost all features (including VSTs) to work in Ubuntu under Wine, but had a problem with WineASIO, which I seemed to require to use the USB sound card properly.

Because of that, I since changed to a DAW called REAPER which is built natively for Linux and works flawlessly and is very nice. There is a program called Yabridge to help run Windows VSTs. I even got more complicated plugins with authentication like Addictive Drums 2 to work using Wine no problem.

If you want a fully FOSS solution there is Ardour which is also great but a little less slick than Reaper IMO.