I mean, the first and foremost logistical issue and more information about the follow-up stuff (unless the Artemis program is simply dramatically scaled back for the foreseeable future) is simply building a fully working prototype of Starship/Super Heavy and the HLS. Until that happens Artemis 3 as planned is completely out of the question regardless of logistics scale and it will be hard to have a really good understanding of the scale of the logistics issues. Fingers crossed for IFT-5 going perfectly next month.

Currently NASA simply does not have a way of landing people on the moon and taking back off again, period.