I just put it in Virtualbox. I only use it for Zbrush and Supermemo. Games I run with Proton instead.

Doing a GPU passthrough or a single GPU passthrough if you have the hardware to do so. VM obfuscation is also handy but can still be risky for kernel-level anti-cheat games, so I don’t recommend doing so to avoid anti-cheat. I like using QEMU and libvirt with virt-manager.