By adult I mean over 18-20 years of age and with adult appearances. Nothing against anime with younger characters, but interested in finding some with older characters.
A lot of people already mentioned the ones I know of and mostly I only know of older shows that were geared to an older audience :/
Outlaw Star? Anything made by Satoshi Kon texhnolyze Megalo Box Baccano? Legend of The Galactic Heroes