When you are drilling new keys but you absolutely do not want to look at the layout map that shows the keys you are supposed to know already.
I almost feel like my piano training has kicked in with my QWERTY technique. I almost move my left hand above my right sometimes to hit certain keys. It’s definitely a lost cause and you are totally right: we know so much more about ergonomics now that if you are going to learn to touch type at this point, you might as well learn an alternative layout.