Yeah, there was an episode of full house with this idea - they used their footprints to tell them apart. I can imagine you couldn’t be doing that all the time tho.
Exact same plot in an episode of Suite Life of Zach and Cody, too, complete with birth certificate footprints to confirm their identities. Although, the episode ends with the mom simply recalling off the top of her head which one belonged to who instead of making any direct comparisons, which always bothered me in an episode about the mom having confused the two in the first place.