On Bottles with the default runner I always had the mouse focus glitch. On Steam Proton Experimental it works great! If you play on BNet, I suggest you switch to Steam.
Overwatch was one of the first DX11 games running well on WineD3D back around 2016-2017 or so. Maybe it was just because of how popular it was at the time, but I remember it being a big deal that it was working. Before that point wine was really only used for DX9 games and below. This was even before DXVK came along in 2018.