Yes, but it depends really on what you want to bind where.
In my case, I have no capslock and I have ESC, TAB, shift, ctlr (on the outermost column) and alt, super, lower, space (on the bottom row/thumb. Obviously with qmk (or similar) you can change what you want, but I assumed it was pretty standard layout (in fact, I changed very little from stock keymaps in qmk).
yeah, I want the ctrl in the ctrl spot cuz I press it with my palm when playing games, currently im using an ergodox-ish board I made