Honestly, it was a bit of luck.
We live in a larger city in the the Midwest. Looked on indeed frequently and applied for a position at a privately owned - medium/large sized company that is headquartered in our city.
In terms of experience they were looking for 3 years of design and course curriculum. My wife had more of that, just in a different industry. Also required a bachelor’s degree and she had a masters in education. A lot of overlap skills but different titles.
It also helped that her hiring manager and two peers on the team were former teachers as well. Luck was definitely involved.
They did request sample work before one of her interviews. She YouTubed a walkthrough on how to use a free instructional design platform and threw something together. A lot of the skills and platform knowledge she has now was self taught through Google and YouTube.
Good luck to you and your wife. Teaching is a challenging career.