Endurance ofc.
Even with endurance your “best” picks depend on which mission type you’re doing specifically. Your Survival aoe DPS frame won’t really cut it in a long Disruption, and your single target CC Disruption frame won’t really cut it in a long Void Cascade, etc
In a Survival you get the most flexibility as you only need high enough KPM to keep up life support, so it’s hard to suggest the “best” frame. You’ll want DPS to be your main focus, so frames like Khora, Garuda, Saryn, Mag, Baruuk are great choices. Frame survivability can be easily solved with a bit of CC and using the environment - find a corridor or a side room for a camping spot to limit enemy LOS and gunfire. If going beyond lvl 1000 (which is a good few hours in) you’ll be mostly forced into shield gating builds, but health/armour tanking and damage reduction can get you pretty far, so you can use something like Nidus for a good long while without too much stress
In Disruption, the things you have to play around are the energy drain and enemy Toxin weapon Conduit modifiers. Both of these absolutely fuck over shield gating builds, and once you’re far enough in, health/armour tanking falls off anyways. You can brute force through both of the modifiers with Vazarin dashes, but if you want safe and reliable picks that don’t rely on Vazarin, then Revenant and Zephyr shine for their Mesmer Skin and Turbulence. Stealth frames like Ash or Loki avoid all risk of enemy Toxin weapons (other than crossfire), and can Vazarin dash through an energy drain round to drop an energy pad at the Demo. If you’re confident using Vazarin to cover you, you can use literally anything, and some great picks are frames like Xaku and Mag. But being confined to Vazarin can restrict build variety a bit (like using Unairu for armour strip)
In Void Cascade, you have an extremely fast mission objective you have to keep up with, while being constantly harassed by enemies. You can’t set up a safe camping spot like Survival, and you can’t set the pace like Disruption. You can bring anything with enough damage output to deal with Thrax and trash enemies, but since the mission dictates where you have to be, you can often find yourself in places with little to no cover, and it’s very demanding on shield gating builds. This again means that Ash, Zephyr, and Revenant are your “best” picks for survivability and keeping on top of the cycling objective. You can bring Vazarin, but it doesn’t bring any damage buffs like Madurai or Unairu to help with killing Spectral Thrax, so when trying to put together a build that covers all bases you can find yourself much more restricted than in Survival or Disruption
