Results may vary but you can always plug it back in after testing.
Toyota’s have no negative effects beyond obviously no cellular functions and the microphone ceasing to work.
I recommend figuring out what the opt-out procedure is too. If I ended up with a Toyota, calling in via the SOS button will start the process of disconnecting the system.
Also note that some may have 3G radios, etc. which are already defunct.
Edit: Fixed typo