Personally I think not having karma limits is nice currently! I understand why they were used but grinding karma as a lurker on reddit was frustrating.
Here is a surprise for you: HRT actually does things to your body. I don’t think this should have been that hard to find on your own, but I can’t judge your circumstances.
Transphobes always make the same tired arguments about “biological differences between men and women” and then scream and run away when you bring up actual science, because they don’t care about the science. They care about being bigots, and using science to make their bigotry look legitimate.