Not the top level directory, obviously.
For me, it would be my Camera directory. Worst case scenario would be to part ways with all the photos and videos I took for 15+ years, including the digital versions of a few hundred objects.
/mediastack. Has all my movies, shows, music, books, audiobooks etc.
/Volume1 ;) guess my system
Probably my back ups, I only have one source anyhow
Simple: Pr0n
Music
Everything else is either easy to replace or it’s stuff I never access