āmayā is my most despised headline word. This article sounds like they may be onto something in mice trials anyway.
This will certainly work 100% of the time, and with no awful consequences.
Remember that Alli pill a few years back that blocked fat absorption and gave everyone diarrhea?
No, but thatās essentially what Wegovy/Ozempic does. Iām pretty sure diarrhea is necessary for weight loss (itās not).
Nah, ozempic and Co change sugar absorption and satiation. People on it primarily eat way less instantly, apparently they just feel full and donāt feel any desire to keep going. It also slows sugar absorption which is why it helps manage diabetes, so that might also play some role
So far weāve found it thickens the intestinal lining and significantly messes with the reward pathways, weāre not sure what the long term effects could be. It seems like at best, you basically have to stay on it indefinitely or regain the weight (which is true of current weight loss drugs)
One of your breasts will grow by 3 inches in diameter. The other gets a much larger and more sensitive second nipple towards the very top of your chest at the base of your neck completely visible regardless of how conservative you dress like.
I think itās called exercise. Iāve seen a meme about exercise. Do not recommend
People hurt themselves that way. Play it safe, walk slowly to the fridge and back.
I always feel insulted when I go to the fridge for a snack and my smart watch says ānice job staying activeā
Kinda reminds me of dinitrophenol (DNP), another miracle weight loss pill that converted stored calories to heat.
Works great up until it literally cooks you to death.
This new method of converting white fat to brown fat to heat sounds like itās in that same neighborhood.
If it works, cool! But be cautious if you see a bottle of some shit claiming to do this at your local pharmacy.
Wasnāt the issue with dinitrophenol not so much the self-cooking effect but it had a really small window of working dose vs toxic dose? So even if you didnāt die of hyperthermia youād die of itās various carcinogenic, mutagenic or other incompatibilities with cells?
Not really if you look into the literature. There were several studies done at Stanford and several hundred thousand people that took it for fat loss and less than 100 deaths from what Iāve seen. Also, a majority of those deaths were from suicide, which is both a sad thing and a terrible way to go. The deadly dose was about 5-6x the normal dose. There was a case of a girl ODing on it to get ready for spring break and I believe she was around 10x the standard dose. Note dosage is based off body weight.
Now there are other issues that can occur because of the MoA it causes you to burn through zinc and magnesium. There are thyroid issues that can occur, as well as the possibility of cataractics. Then thereās the proton slip and electron leakage within the mitochondria. This is what causes a majority of the problems as itās a positive feedback loop for negative cascades. That can be almost entirely negated by keeping dose lower and doing your cardio. It can be done safely if you know what youāre doing but most people arenāt that reasonable.
Someone wrote an interesting book on it and took more of a conspiracy standpoint on it claiming it could be effective fat loss but because it was cheap and easy it would cut into big pharma making money. Canāt say I agree with everything in the book but there was some useful information.
Thereās also a newer compound called BAM-15. In research itās more effective at fat loss and can be taken at much higher doses safely. I believe they got up to 20x the dnp standard dose without negative side effects in the lab rats.
coming at a time when temps are going up, permanently (well, for any human lifespan) people eating too much then burning calories to dump as waste heat completely tracks.
Iāve been wondering for a while if burned fat releases protein as if you had eaten the fat
Scientists have figured out a ton of things in a lab setting. But most of that is not something that scales up to the real world.