For me, in no particular order: Firewatch This War of Mine What Remains of Edith Finch Gone Home Papers Please Doki Doki Literature Club I Have No Mouth and I Must Scream
Cyberpunk 2077. Talking to Angel/Skye in Automatic Love. I was in an emotional state at the time where that dialog really got me.
Also Jackie’s end. That got me good. Animators really nailed that scene.
Night in the Woods. It’s hits you in places you never knew were sensitive until you’re acutely aware of each and every exposed nerve.
Abagail Foy in Prey (2016)
That one chapter in Spec Ops The Line
The scenes where you go back to your childhood home in Wolfenstein The New Colossus
Firewatch
Nier Replicant really hits hard (even more than Nier Automata)
Rime completely wrecked me. I downloaded it because it looked like a cute fun puzzle game. I was not prepared for the emotional journey it would take me on.