By adult I mean over 18-20 years of age and with adult appearances. Nothing against anime with younger characters, but interested in finding some with older characters.
+1 for Black Lagoon, W anime pick.
Also for Ghost in the Shell, PatLabor, and Redline.
I will also add on:
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Jin-Roh/Jin-Rou (not the Korean live action from 2019), but it does briefly show a child on screen as a supporting character, and I dont remember if Kei was over 18-20 or not
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AD Police Files, and its related series Parasite Dolls (unfortunately, the other related series Bubblegum Crisis and Bubblegum Crash are disqualified because Nene Romanov is 18 and Priss is 19, both under 20)
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Space Dandy (maybe, that anime had like a billion characters and I dont remember if all of them were adults or not, but its not exactly a kid oriented anime)
Black Lagoon is one of the most underrated shows. People who have seen it usually love it, but not enough people have seen it.
I need to watch Jin-Roh sometime.