Yes, so I want to browse all but actually control the content, block instances, block keywords, etc… currently using Jerboa, but not married to it.
Apparently it is a thing - I found out how in another thread: https://kbin.social/m/kbinMeta/t/23632/How-to-block-an-instance-on-a-personal-level
“For example, you want to block lemmygrad.ml - go to kbin.social/d/lemmygrad.ml (d for “domain”) and from there you can block the whole instance (click on the 🚫).”