My friend works out and takes pain meds frequently.
He also complains about yearly kidney stones.
I have never had a kidney stone. Where he’s on his 8th one.
Was he on narcotics? I’m finding no link between Acetaminophen or Ibuprofen to kidney stones. Just drink more water.
https://www.utsouthwestern.edu/newsroom/articles/year-2023/june-prevent-kidney-stones.html
https://pubmed.ncbi.nlm.nih.gov/30829133/
Ibuprofen is mostly processed by your liver as well. Acetaminophen uses a bit of both.
This appears to occur predominantly systemically in the liver [1,10], but may occur pre-systemically in the gut as well [11]. Ibuprofen is almost completely metabolized, with little to no unchanged drug found in the urine [1,9,12].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355401/
Acetaminophen (APAP) is normally metabolized in the liver and kidney by P450 enzymes. No toxicity is observed with therapeutic doses of APAP.
https://www.goodrx.com/acetaminophen/is-tylenol-acetaminophen-bad-for-your-liver-or-kidneys
https://pubmed.ncbi.nlm.nih.gov/8669426/
Tylenol (acetaminophen) is almost completely broken down by the liver. During this process, a toxic chemical forms. Normally, the liver makes it non-toxic. But if you take too much Tylenol, the liver can’t properly process it all. The toxic chemical can then build up and poison liver cells.
https://www.goodrx.com/acetaminophen/is-tylenol-acetaminophen-bad-for-your-liver-or-kidneys
