it does say that theres only 20 in the label, but im more pissed about the waste. everything couldve been put on 3 trays

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83 points

The only time I’ve seen something like this is when my doctor really wanted me to try an anti-depressant, so he gave me a perpetual supply of free samples.

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15 points

Don’t antidepressants take weeks to start working?

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57 points
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A doctor said this and it was such a good metaphor: imagine that you have a 3000 year old machine (which no one understands anymore) with a bunch of cogs and gears, and you’re looking down at it from above. You’re trying to fix a gear that is slightly out of alignment further down in the machine, you can’t really tell which one it is but you know roughly which area, and to fix it you drop a rock into the machine and watch it fall down.

That’s what we’re doing with SSRIs. We’re dropping a rock that manipulates our serotonin, which gives a bunch of effects but not the one we’re after. The one we’re after is somewhere down the line. It’s affected by processes that are affected by the serotonin somehow. We’re not exactly sure which one it is, but we know that if we drop the rock in there it will make the gears align sooner or later.

Which is why it takes time, and why it has some odd effects on people sometimes.

edit: added a detail I missed, to make it clearer.

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31 points

That’s a good metaphor! I’m not sure about the rock though, throwing a rock into a complicated machine doesn’t seem like the best idea. I’d consider replacing it with oil, where it needs to cover the gears at the top first before it can drip down.

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20 points

“the rock may or may not cause the inability to cum and sleep”

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1 point

I totally understand that this is a necessary process for anti depressants but damn it sounds scary as fuck. “Eat these brain chemicals and come back and see us in a couple weeks”

“How does it work?”

“Fuck if I know it’s kind of like throwing a rock at an old machine. Just make sure you let me know if you experience any of the long extensive list of potential side effects!” Like damn im for sure not a doctor but that sounds like russian roulette with brain pellets to me. If Ecstasy (which was invented by a pharmacutical company to be medication) can permanantly fuck up your brain I would bet money that these pills certainly do the same. I bite my tongue anytime someone mentions they are considering it or talking to a doctor about it, their choice. But man it scares the fuck out of me. Ill just continue to sleep all the time and stay angry lol

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-6 points

This is a great metaphor for why psychiatry is pseudoscience

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8 points
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Yes and no, also i am not a medical professional.

For classical antidepressants Chemicals tend to function pretty fast but the effect is designed to be subtle because you need to live a normal life, capable of dealing with and feeling both ups and downs. not be perpetually smiling or brain dead.

After some time “a few weeks” of taking a daily dose your body and mind adjust to the subtle changes causing a stable therapeutic effect. At least thats what I understand is the idea.

But lately there is also sm of a psychedelic renaissance of medicine and they work entirely different where a single dose within a therapeutic setting creates a longer lasting feeling of increased well being.

Nasal Ketamine seems to receive allot of attention, near instantly improving the condition. They tend to need 1 dose every 5 weeks so its less addictive then classic medicine. But i do admit it instant improvement for treatment resistant medications is a bold claim and still subject of more research.

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4 points

The side effects can last for weeks. It’s like a really shitty onboarding process. For some, the side effects are not bad. Personally I can say that the first 2 to 4 weeks are usually filled with nausea, extreme fatigue and exhaustion.

The way that these sorts of meds have been described to me is that “they give you a leg up”, meaning it gives you just enough of a “boost” that you might actually follow through on therapy and the strategies it offers.

It has been years now, and still no luck. I’d love to live a normal life, whatever the fuck that means lol

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1 point

It depends on what you mean by “start working.” The first time I took a sertraline, I felt absolutely baked, but I feel like it took weeks for the desirable effects to take hold.

Then again, my doctor also told me that something like 60% of the effects are a placebo.

Regardless, yes, he would give me like a month of these individal samples at a time. I’m not sure how he swung that. It was like 2003 or 2004.

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