What are you all playing! I’ve been playing a lot of lies of p and have been dipping my toes back into binding of Isaac!
I can’t really compare too much to P4G, since I never got very far in it (I missed the QoL improvements).
I think being able to save in safe rooms let them expand the Palaces/Dungeons, which I could see making the game drag for some. Personally, I enjoyed the safe room mechanic since it meant that I could play for short times if necessary, which let me “pick up and play” much easier.
The sleep function is pretty nice, but I like to swap games relatively frequently; so being able to save frequently is still critical for me. Plus at the time, I was just playing on my personal computer, so I couldn’t leave it running, even if I wanted to.
For P5R, I suggest only playing for an hour or a two at a time; I think it helps keep the game from dragging. For me, it helped keep the exploration aspect fun since I didn’t have to rush to the end since I was probably not getting there in this sitting anyways.
If I understand correctly, you own a Steam Deck. I haven’t tried it, but this plugin could be useful for your use case.