Also the biosphere 2 missions.

Those…. Ended “well”.

Antarctica trips have all of those limits you mentioned, they’ll just be worse for Mars. While they can operate sort of freely for a few months, once winter sets in, they are just as isolated as another planet. They just get the advantage of easier setup then Mars.

those doing a antartic winter may as well have the no suited outdoor time, poor clothing choice will be death almost as quick

I’m thinking a lot of the equipment is different as well, and since they mention simulating equipment malfunctions, that plays an important part, especially with the additional limitations/simulated dangers.

Hard to say - There’s still a lot of hazards yet to be accounted for: a lot more radiation exposure, literal poison in the soil, severe weather, safe and affordable supply chain, etc.

I guess that depends on what you consider reasonable. I figure if they’re starting with simulations such as this now, it’s reasonable to expect an actual manned mission in maybe 20 years.