The first thing that comes to mind was my first play through of Yakuza 0. Majima spends so much time winning stuffed animals for a little girl that lost her dad. Part way through the quest line she starts calling him dad and it made him so happy. It warms the heart and I could not stop smiling.
Mass Effect 3: I am Garrus Vakarian and this is now my favorite spot on the Citadel!
When you start the fight on the dam wall in BL2 after Roland is captured & the music starts. That was the borderlands moment for me that got me sucked into that universe
The “Invaders Must Die” fight in Hi-Fi Rush had me beaming ear to ear. By that point in the game I was so in tune (intended) with the mechanics I just chewed through the fight, headbanging the whole time. One of my all time favourite gaming moments.
Borderlands still tends to make me crack up. dem bandits are funny when they die