calebcharles

It’s a very funny joke. A white flag was literally their flag. It caused some issues when they tried to surrender and kept getting shot. So, they had to up their design game.

Wow, bulk downloading you rascal.

Here’s the summary:

Background

Recently published two-sample Mendelian randomization (MR) studies showed that genetically predicted coffee consumption may be associated with increased risk of Alzheimer’s disease and intracerebral hemorrhage but associated with a decreased risk of small vessel ischemic stroke. We aimed to investigate the effects of genetically predicted coffee consumption on magnetic resonance imaging (MRI) markers of cerebral small vessel disease and brain volume using the two-sample MR method.

Methods

Twelve single nucleotide polymorphisms (SNPs) in up to 375,833 individuals were used as genetic instruments for cups consumed per day of coffee. Another four SNPs from an independent sample were used to perform the replication analysis. Three SNPs in up to 45,821 individuals were used as genetic instruments for high coffee consumption vs. low/no coffee consumption.

Results

Mendelian randomization analysis showed that coffee consumption (cups/day) was inversely associated with gray matter volume (beta = −0.371, 95% CI = −0.596 to −0.147, p = 0.001). Replication analysis and multivariable analyses after adjusting for other risk factors confirmed the effect. High coffee consumption was also suggestively associated with decreased gray matter volume (beta = −0.061, 95% CI = −0.109 to −0.013, p = 0.013) compared with low/no coffee consumption. All analyses did not find an effect of coffee consumption on other outcomes including white matter hyperintensity volume, mean diffusivity, fractional anisotropy, brain microbleed, total brain volume, white matter volume, and hippocampus volume.

Conclusion

This two-sample MR study showed that genetically predicted higher coffee consumption is causally associated with reduced gray matter volume of the brain.

You would think a hijab is more sanitary than hair in a food service place.

We’ve had fun playing Elevenses, Odin’s Ravens, and Silver and Gold. Small, mostly card games but beautiful art and engaging gameplay.

Developers, developers, developers, developers, developers, developers, developers, developers, developers!

Here I am in the minority with strong chicory with heavy cream. All the bad breath; none of the drugs.

Oh boy are they unhinged.

Breathatarians intensify.

They call it the war of northern aggression. There “ain’t nothing civil about it”.