Your character starts randomly weaving over-complicated, nonsensical conspiracy theories about other characters and events in the game.
“Oh my god… the sweet old lady who lives next door is with the Illuminati! I have to kill her before she gets me!”
No wait this is actually an amazing idea, if you let your hunger meter/other resource go down far enough, it gives you unskippable objectives to do HORRIFYING things.
Get a bit too tired? You get an objective to break into someone’s house to sleep. Have to kill someone to do it? Too bad.
Too thirsty? That old woman’s IV bag looks like a great hydrator.
Hungry? Let’s hope you aren’t near any children’s hospitals…