The world’s first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.

The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side effects.

“We want to do something to help those who are suffering from tooth loss or absence,” said lead researcher Katsu Takahashi, head of dentistry and oral surgery at Kitano Hospital. “While there has been no treatment to date providing a permanent cure, we feel that people’s expectations for tooth growth are high.”

Following this 11-month first stage, the researchers will then trial the drug on patients aged 2-7 who are missing at least four teeth due to congenital tooth deficiency, which is estimated to affect 1% of people. The team is recruiting for this Phase IIa trial now.

-7 points

as exciting as this is here in the US at least insurance prices are not affordable and neither is basic health care

this sounds like something Biden, Trump, and their donors will benefit from though

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25 points

Can’t wait for it to be $700 a dose.

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2 points

Can’t believe the dental fluoride lobbyists are already flooding lemmy with disinformation :P.

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39 points

Beat a couple thousand for an implant. Progress!

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17 points

Me too! That’d be amazing! Forget a root canal. Let’s yank it and start over.

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5 points

Tooth growth putting! Absolutely no way that could cause horrors!

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9 points

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7 points

That movie “Teeth” is about to have a resurgence of watchers I bet.

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1 point

My nose teeth could come in handy. So would anus teeth. I never had anus teeth, but I’ve plugged many a toilet. Imagine that never happening again to anyone! Just add 3 or 4 molars there and away we go!

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2 points

I just pictured anus teeth chomping at the shit to break it up as you take a crap, and for that, fuck you.

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2 points

But functional, you gotta admit 🤪! Or should I say butt?

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1 point

Like that one scene from The Algebraist by Iain M Banks.

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9 points
*

Between this and the tooth decay “vaccine” (that replaces acid producing bacteria in the mouth with an alcohol producing kind) there’s no reason my kids shouldn’t reach old age without a full set of their teeth.
Aside from that whole, climate-change-driven-collapse-of-social -order thing.

I better avoid it through. I had four of my otherwise healthy adult teeth removed early on to avoid crowding issues. No idea where they’d fit in my head now if they grew back

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4 points

So now instead of getting plaque, I’ll just get tipsy on my saliva? And no one told me?

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6 points

Stop eating candy! You will get drunk!

flying chancla

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13 points
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I had a new tooth start sprouting on the inside of my mouth a while back. The new nerve in it was horribly sensitive, and I thought I had a cracked or damaged tooth before the dentist told me what was going on. I would rather have a nerve-less implant than a new-growing tooth like that again, given the choice.

Edit: It was a random new growth along the outside of my gums in my 20s.

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If they can regrow nerves, I think there are some implications that are slightly more exciting than teething…

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