FYI, every melatonin supplement is way too high of a dose and is completely saturating your melatonin receptors, leading to tolerance and dependency.
Your body is not producing more than .5mg of melatonin naturally, so taking a 5mg supplement is far too much. And they sell 15-20mg too. If you can find 1mg that’s best; but what’s even better in the long run is not using it!
I know it’s said over and over and over, but regular exercise!! There are certain types and times of exercise that are more effective, but generally speaking, exercise promotes serotonin conversion to melatonin and makes sleepy time easier.
Absolutely! Additionally, morning sun is another great way to regulate your circadian clock and let your body start its internal timer for melatonin release.
In the winter, I use a light box for seasonal affective disorder, and in addition to feeling much more energized, I find it helps me get more consistent sleep!
We buy 1mg. Once we couldn’t find any so we bought 3mg and cut them in half. I found it interesting that OP used actual dosage for caffeine but not for melatonin. Three pills could be 3mg or 60+.
That’s great! I really do think 1-1.5mg is the upper limit anyone should use, although it’s still higher than free melatonin concentration in your brain it’s a much more reasonable dose in comparison.
And I think most people who don’t understand melatonin go straight for the 20mg, so we’re probably talking 60+.
It really blows my mind that in this day and age there are no regulations or at the very least warnings or guidelines regarding melatonin supplements.
The gap in FDA policy for prescription drugs vs supplements is vast. Supplements have very few regulations and restrictions that create a lot of potential issues for the uninformed consumer.
Bioavailability of oral melatonin is very poor though. IIRC it’s about 10%, so that 5mg sounds about right.
That’s a great point! You’re definitely right. I’m seeing somewhere between 10-30% depending on patient population.
That being said, since we are naturally releasing .5mg, another .5mg is already double the normal concentration.
Another major point of consideration though would be formulation, as that is going to have a large effect on the half life of the dose in your system. Even if bioavailability is around physiological concentration at 5mg, the duration of the exposure being much longer than the time it takes for natural release would still have negative impact.
All this being said, definitely never a reason to go above 5mg
How is it with Quetiapin Sandoz? One pill is 25mg and i’m tired until noon, so i usually cut them in half.
Quetiapin is an antipsychotic medication, not the same as melatonin which is a naturally occurring hormone.
700 mg of caffeine, is that like 29 coffees in a row?
There are no winners here.
Source: Tried for years to overpower the insomnia from my ADHD meds with melatonin, weed, CBD:THC edibles, booze, kava, diphenhydramine, etc. before finally going cold turkey on my adderall. With enough stimulants, it doesn’t matter how much melatonin you take; you’re not gonna have a good night’s sleep edit: but you’ll also be too tired to be productive or to do anything fun
I have no issues sleeping on 120mg of Vyvanse, I even find it easier to sleep.
Are you sure you’re not misdiagnosed?
Certainly possible, but I’m sort of a textbook mild case of ADHD, just with the side case of insomnia being fairly prominent (which was true even before medication). Everybody reacts to medication in different ways, so I’ve just found I have to rely on coping strategies more than medication for my case. It’s not a big deal and I’m at a point in my life where I can manage my ADHD symptoms in a way that doesn’t affect my life too much. So for me, the side effects of the medication exacerbate my preexisting insomnia to the point that the drawbacks of adderall outweigh the benefits for my particular brand of ADHD.
Did you take slow release aderall? My aderall is worn off before I go to sleep and I actually sleep better since I take aderall because I spend more energy during the day.
No it’s IR, but taken 20 mg in the morning and then 10 mg in the early afternoon. It just always wound up with the physical effects lingering much longer than the mental effects, so if I tried skipping the afternoon dose, then I’d wind up totally scattered and useless from about 3PM on.
The XR once in the morning worked a little better, but for whatever reason didn’t really help the same way and I still had the insomnia from it.
this is dangerous.
Lmao how on earth is this dangerous? Or does this classify as ‘mixing uppers and downers’ for you? Because it definitely isn’t, melatonin is barely more psychoactive than a sugar pill
My understanding of melantonin is its something you wanna regulate and spread out, like maybe once a week. When I took it in combination with a zinc pill, man I would be in walking dream mode before I even got to my bunk.
I did some reading at the time about the zinc and melotonin, and I could be confusing the mexhanism and effects of the two.
Or I might be entirely wrong and I thank you, and you other guys for calling me out.
I am too lazy to read up on this right now so while I would be wary of combining the two, it might be ok and I might just be wrong .
I have had a long day and gonna zonk now without any supplement heh. Thanks for replying, I prefer to be corrected and its always fun learning I have been wrong my entire life about something, heh
Don’t mix uppers and downers. That’s how John Belushi and Phillip Seymour Hoffman died.
