7 points
*
this has been known among users of these drugs for quite a while now. They bond to the same receptors, so they interfere with each other. You can mitigate this a bit by going 24 hours without your SSRI/SNRI (ie skipping the dose that would precede the trip), and increasing dose of the psilocybin by ~1.5x. Or so I hear
6 points
Also pretty dangerous to do MDMA without pausing your SSRIs and just about deadly to do them when on MAOIs
2 points
2 points
6 points
Oh yes. Antidepressants have definitely reduced the effectiveness of various drugs for me.
1 point
Can confirm.
