Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) have developed
This article is garbage but I’m a molecular biologist and the publication they’re talking about is really neat.
The “ELI5 to the point of maybe reducing out the truth” way to explain it is that the researchers can add “flags” to proteins associated with immune responses that make cells pick them up and examine them. This is shown to work for allergins (so say, add a flag to peanut protein and the cells can look at it more closely, go “oh nvm this is fine” and stop freaking out about peanuts) as well as autoimmune diseases (where cells mistake other cells from the same body as potential threats).
It’s not nearly to a treatment stage, but tbh this is one of the more exciting approaches I’ve seen, and I do similar research and thus read a lot of papers like this.
There’s a lot of evidence that we are entering a biological “golden age” and we will discover a ton of amazing things very soon. It’s worrysome that we still have to deal with instability in other parts of life (climate change, wealth inequality, political polarization) that might slow down the process of turning these discoveries into actual treatments we can use to make lives better…
Still, don’t doubt everything you read! A lot of cool stuff is coming, the trick is getting it past the red tape
Wealth inequality won’t stop these discoveries making people’s lives better, it will just ensure that the 1% live forever in perfect health and the 99% get to watch their kids and grandkids get sicker as the environment, living standards and employment situation deteriorate, until automation gets to a point where the working class are no longer required and can be safely left to starve or killed off.
Americans invest milions in healh evolution and only 1% of the americans can use it. On the other hand every other country with a free heath care will provide the solution discovered by americans for free to their people. Americans dying to keep the world alive. This is really fucked up.
This is basically my fear, also. How can I retain hope that new, amazing treatments will help people if we don’t even have equitable access to the current treatments?
For example, we still make people seeking medicines for mental health try going through a gauntlet of dependency-forming drugs from greater than half a century ago (that have been shown to be effective in less than half of people who take them) before insurance will pony up for contemporary alternatives (that work much more often).
I don’t work in the clinical space so don’t trust me too much… but jeez we have so many things to solve before the “bio golden age” really helps normal people
“Red tape” eh? Shit if I had MS or AIDS I’d get some red contact lenses and some fake white fur, just don’t ask where the rat tail is attached, and be in for clinical trials in the AM. “I’m a rat it’s fine. I mean squeek squeek.”
That is so funny… tbh I know I’d get shit for this professionally, but it definitely frustrates me that we don’t allow people with few other choices to have access to crazy, left field treatment stuff.
My best friend died of a specific and rare cancer this year. We know exactly how that cancer works on a molecular level, and we’ve found a few chemicals that interfere with the function of those cells in vitro while not seeming to harm average cells.
Sure, it’s a huge risk to take that drug that’s only been tested in a dish, and it wouldn’t be worth it for most people. But he was going to (and did) die within a year of diagnosis. It’s not like he had other options.
Maybe he should have invested in a rat costume ;)
Every time I see articles like this I’m very happy for everyone having those horribly debilitating and deadly autoimmune diseases.
Then with some shame I hope it might maybe one day also cure my slightly debilitating non deadly simple allergies one day.
Yay it seems it might be good for both!
Well, you’ll also be happy to know that they started this work on allergin way before working on autoimmune disease, and in my opinion, the evidence that it works for allergies is much stronger than how it works for autoimmune diseases! Not necessarily because it won’t work for auto immune stuff… just that they have done less confirming.
I have severe allergenic asthma so I was excited about it too 😁
The privacy on that site was horrible, and I stoped de-selecting vendors who want permission to track me after two minutes.
But I wanted to ask you: are there any biologics based on this discovery in phase I or even II at this point? Any odds on one of them making it to III?
(also re: your last comment, read William Gibson’s The Peripheral; you are describing his “jackpot” scenario)
privacy on that site was horrible, and I stoped de-selecting vendors who want permission to track me after two minutes.
Just open the page in a private window at that point, and click the “yeah sure track everything bro” button.
“Private browsing” is for not letting your mom see your porno history on the family computer, it does fuck all for you being tracked online.
Hope it’s not a stupid question but would this kind of thing work for ankylosing spondylitis??
I ask because I suffer from AS the doctor’s that I’ve gone to are always arguing whether it’s an autoimmune or an autoinflammatory disease, and on the web it says that the underlying mechanism is either of the two as well.
So it’s not clear to me whether it’s one or the other, or if itimplies the same thing. I’ve read a huge deal about AS but I’m not really good at biology or medicine to understand a lot.
Honestly the only reason I’m commenting -and asking- here, is because I want to have hope that this actually leads up to something that can help me stop this fucking pain that makes me feel like I want to die (figuratively) but I’m afraid of this being a clickbait article.
Also my English is not the best so sorry for any mistakes and for the long comment.
Do you take humira or another medicine for it? I have AS too and it’s bearable with Humira for me. But yeah if this research leads to something that would be great
Oof I’ve had an experience with these meds…
I used to take Humira for 5 years but my country stopped delivering it (I used to live in Venezuela), then I moved ti the US and started Humira again, but it was about 30-50% effective only, I still had a lot of pain
I then went through Cosentyx and Taltz, none worked. Then I tried Enbrel, same effectiveness, got it through a foundation. Healthcare didn’t want to cover it and the foundation didn’t approve me if I had Healthcare.
Got sick in the US, lost all my money (due to lack of money), so I spent the little I had saved to return to my country, moved to Brazil and I’m about to start Golimumab (Simponi) tomorrow, hopefully it works because I haven’t gotten medication in 2 months and the pain feels unbearable.
Having said all this, if there is a speck of a chance that this helps people with AS and other similar conditions, it would make me happy. Having this kind of pain is unbearable.
Sorry for the long comment, I suddenly wanted to rant about this!
I’m sorry! My knowledge of this process does not extend to the point where I could even give you a hint of the answer. To be honest, it would require me diving into the underlying mechanisms of your condition, and it sound like your doctor has said it isn’t even settled science why it’s happening, so I don’t think anyone can tell you if this would work for you.
I know that isn’t what you wanted to hear, but two things: 1) this treatment is a long way off anyway, so anyone will have to wait for it to be available, and 2) there are probably many other treatments coming down the line for your condition… even if those also take a long time.
Anyway, I’m sorry for your pain and that I couldn’t help! Honestly, I hope something will be available to help you many years before this becomes a treatment option.
That would also work for cancer then, wouldn’t it? Since the mutated cells hide from the immune system you can mark a few to get the immune system to take a look and realize that shit is happening, or am I oversimplifying too much?
There are immunotherapy treatments for cancer already. Infections and cancer use the immune system the correct way: “tag” the problem cell/virus part with an antibody, make a lot more antibody and flood your body with it to clear the problem cell/virus.
This is the process a vaccine uses. The old vaccine method is to take a bunch of dead bacteria or inactivated virus and put that in your body. Your body should identify it and begin making antibodies against it. If you do get exposed to the disease, your body is full of antibodies which can immediately clear it, rather than letting the infection/cancer work for a few days without much of an immune response.
An autoimmune disease, a body “tags” its own cells. Then the immune system invades the person’s own tissue.
I have celiac disease. If I eat gluten, the enzymes I use to digest gluten become tagged. Unfortunately, humans make one gluten enzyme (TG2) that’s found everywhere in the body. A third of celiacs will have their thyroid tissue affected if they consume gluten.
One particular antibody, IgE, is known for extreme reactions to antigens. These are the ones known for the immediate and life-threatening allergies (peanuts, shellfish, bees, wheat).
This new stuff appears to be a way to tag antibodies or antigens or memory T cells (they hold the “blueprints” to make antibodies really quickly after your natural antibodies go away) and have the immune system “re-evaluate” the antigen. I’m guessing from the post above and a little of the article. I haven’t heard of this process in the body before.
Cancer itself is not autoimmune (autoimmune inflammation can make it more likely to happen, but tumors don’t form directly through autoimmune mechanisms). So the first pathway used for normal vaccination is what’s needed. The difficulty lies in knowing something in each specific cancer that would make a good antibody target. It is a person’s own cells and DNA, so a lot of care has to be taken to find an appropriate antigen. Immunotherapy treatments that exist are really specific to certain types of cancer. They have much less severe side effects than radiotherapy and chemotherapy.
You’re not oversimplifying from my description, my description was just too simple itself! Unfortunately, no, it wouldn’t work like this. The whole idea is that the cell would pick up anything and discover that it isn’t as dangerous as it thought. That’s the opposite of what we’d want for cancer cells!
Luckily, there are many, many other treatments for various cancers coming in due time, also. My research is actually closer to cancer research than immunology, so I can tell ya-- there’s good stuff coming!
getting it past the red tape
And into the grey matter of those damned antivaxxers. 🙄
I’ve been following cures like this for years. There are three candidates in phase 2 trials right now that appear to work, they’re mostly figuring out the doses needed and there’s a big question on how long they last. Hopefully permanent but we don’t know for sure.
Diabetics have just been so beaten down by this whole thing. I was told the cure was 10 years away 40 years ago. Even if the technology described here works we could be another 15 years before we see it. Researchers said it could be here as soon as 5 years, which is true if unrealistically optimistic. I believe the cure is coming but I’m not holding my breath until I’m actually in front of a doctor about to receive the cure whatever it happens to be.
It’s a clash between scientists needing to be optimistic about their findings to maintain funding and real people needing it asap. We need to fund more medical research outside of for-profit corporations and increasingly expensive academia
Imagine if there was a global fund for disease cures that all the industrialized nations poured their money and resources into.
If you’re talking about The Global Fund, they only attack very specific diseases, mostly eradicated in industrialized nations but persist due to poverty (like malaria).
I can just imagine the opportunities for corruption in such an organization.
Imagine if the research and development of treatments and vaccines for endemic pathogens and genetic disorders were… you know… socialized
I hear this argument all the time, but the majority of the major research comes from the US [1]. My inclination is that, because the US is for-profit, the cures are developed faster and the science is here. The socialized nations lack, it’s a fact, and it’s certainly not for a lack of resources
It seems like the COViD model worked pretty well. One of these days I’d like to better understand the process, but I believe it was something like ….
Vaccine developed by private companies but with a lot of government funding but more importantly, massive contracts at a fixed price.
It’s like all the revolutionary battery technologies, computer storage technologies, fusion, cure for cancer, anything with graphene in it, cure for immune diseases and all that. People just love to write clickbait articles about this stuff.
Developing these ideas in the lab takes decades, and turning those ideas into actual products takes even more time. When you see articles about these topics, you can be pretty sure you’ll never hear about it again.
Edit: Just to be clear: technology is going forward all the time, but news articles tend to fucus on things that are interesting or fascianting, and extrapolate from there. The technologies that actually end up becoming widespread might not be interesting enough to write about.
The real reason it takes time is because we try not to harm people even in experimental drug testing. It would be much faster to simply toss shit at the wall and see what sticks, but that’s not exactly humane. So we have to find analogues that hopefully mimick humans will enough, but they don’t really work well. So it takes lots of time to build up enough evidence with those preliminary tests to convince the safety board to allow human trials. Then trials have to slowly scale up to limit the amount of people harmed by unforseen effects with a lot of time between as the safety board reviews the previous results before allowing the next test.
It’s all good to do, but it does make development frustratingly slow sometimes. Especially when people are actively dying waiting for the new drugs.
Looking at the price per kWh for commercial batteries tells me that we are seeing the battery revolution right now.
Graphene is already commercially used in some applications:
There are already very effective cures for some types of cancer (note that the differences between the many types of cancer can be huge and so the effort and time needed to create cures will also be very different. some treatments also are effective but not completely understood yet, like for bladder cancer)
Nuclear fusion devices are commercially used in material analysis (mostly in the semiconductor industry and in ore processing). There are different types in use – some even use thermonuclear fusion on a small scale.
It all seems like super crazy superconductor level tech until it becomes mundane and part of peoples lives … then we stop noticing how amazing it really is.
Oh, I’m not saying that development isn’t happening. I’m just saying that the articles you see on the magazines and papers tends to focus on wild technologies like grinding metals into nano particles and using that as a battery. Yes, New Scientis (or was it Scientific American… can’t remember) actually wrote about that stuff and predicted that cars of the future would use this energy source. Ideas like that get reported bacause they sound cool, while incremental upgrades to plain old lithium ion technology gets ignored by the tech magazines.
I’m really looking forward to seeing graphene and carbon nano tubes being used in various applications. Scaling up your production usually is the real problem though. Even if you’re able to produce a few micrograms of something in the lab doesn’t mean you can actually turn that into a commercial product. The transition from NiMH to Li-ion seemed like that for a while until one manufacgturer (was it Sony or Philips?) took the risk and started making those batteries in massive scale. Consumers loved that, and before long everyone started using this wonderful new technology. When someone takes that risk with graphene, we’ll probably start seeing it everywhere.
Sort of, they did find a covid vaccine pretty quickly. I’m hoping this is part of that research.
mRNA vaccines had been in development for about 20 years prior to 2019. We were lucky.
Graphene actually is used in small amounts in a few places today. The difficulty is still in scaling up production.
I won’t really know which computer storage technologies you’re referring to. There are plenty of different ones, most of them just have niche applications or are too expensive to replace today’s SSDs for general use, as SSD technology have gone a long way. It’s a similar story to batteries, honestly. Lithium is still just the cheapest for what it does, but alternatives for niche applications exist.
Fusion needs more funding, no way around that, otherwise the theory is sound.
But of course, it is true there’s tons of clickbait. But promising new developments do exist.
Before SSDs became widespread, the tech news would usually find a way to include an article about a revolutionary new storage technology that could store 100x more than a CD. Yes, that was a long time ago, and no, we didn’t hear from those technologies ever again.
I was thinking of forwarding this to a friend with type 1 and remember the tale of misery from the last one I sent. Exactly what you said. She’s 38. Don’t get her hopes up.
Reversing type 1 is a complete lie. Unless you can somehow magically reatore pancreatic cells
You actually can, that’s the easy part surprisingly. The hard part is keeping the body from killing beta cells after you induce their growth which is why it’s not cured yet.
Look up Vertex. They have stem cell derived beta cells they’re looking to put in a pouch to avoid immune response, but AFAIK the production of the beta cells is a solved problem. They implanted those cells in someone and he’s seemingly cured.
https://www.nytimes.com/2021/11/27/health/diabetes-cure-stem-cells.html
The issue is that cure currently comes with life long immunosuppressants.
A few people asked for more information about these trials that I referred to above. In theory if you can cure one autoimmune disease you should be able to use the same method to cure any of them. Obviously we don’t know that for certain and diseases like Diabetes has the extra step of inducing the growth of new beta cells to produce insulin (more on that below)
That said, the three trials I referred to are Celiac specific. I have this and T1D so those are the two I’ve been following most closely, but I definitely dive into news on ms or any of the other autoimmune diseases.
Note: all of these entered phase 2 this year. They are in the EARLY EARLY stages of that phase, so we should see results in 2025/26 for these. I am also ignoring any trial not in phase 2. Also note that several diabetes and ms cures are essentially variants of these, and many of them are running in parallel.
KAN-101: This is from Anokion and happens to have a trial in my area, hence it’s the one I know the most about. This one works by targetting the liver where the relevant immune cells are produced. Even in their phase 1 trial they found that patients had a dose dependent reduction in IL-1 (a cytokine that your body releases in the presence of gluten if you’re celiac). As with all these trials they need to determine what dose is needed to be a full cure and is it permanent?
TAK-101: This is an MS cure that was adapted for celiac disease, originally developed by ImmunisanT. They also have several other variants of this one, including T1D. Unfortunately their website seems to be down. Takeda is handling the clinical trials here and last I heard they’re waiting for the celiac results before pushing forward with the others, but they expect them to move quickly at that point. Here’s a video by one of the researchers behind this.
TPM502: I know the least about this one, it’s from Topas Therapeutics and they recently announced the start of phase 2 trials in Finland, Norway, the Netherlands and Sweden. [more]
I should emphasize that there is no guarantee any of these treatments will work and everyone is tired of the latest “breathrough” that we never hear about again. Some of the trails above had to go back to the drawing board after hitting phase 2, TAK-101 is a newer generation of “Nexxvax” which if you google that you’ll find articles about its cancellation.
Then Diabetes has the problem of beta cells needing to be restored or replaced. That’s looking feasible either by transplanting adult cells, stimulating the growth of new ones using stem cells or a similar concept. One proposal hides the beta cells from your immune system entirely inside a scaffold. That last one is more of a new treatment than a cure, but it definitely beats what we have now.
The good news is that work IS being done in this area, progress is being made, and I know at least with KAN-101 they have demonstrated it showing results. The cure is coming. Even if most or all of these trails fails the fact that they’ve seen the results that they have is still really good news.
Again, it’s coming. It’s just not in a hurry.
If there was sufficient funding and enough people on it, we surely could have gotten so much further in so much less time.
Of course you can speed up such developments only up to a certain degree. But given the state of so many important research fields, we’ve surely not scooped out the whole potential.
I’ll come back in a few hours when I’m on my computer and give you the list. I’m sure others will be interested in it as well.
I responded to my own comment above with more info, check it out here: https://lemm.ee/comment/3624282
What phase 2 specifically if you don’t mind sharing? They mention in this article starting with a phase 1 for celiac and then a phase 1 for MS.
I’ve also seen so many of these over a couple decades now. I have RA and MS and often times while hope can be important. As Red said, hope is a dangerous thing and can drive a man insane.
I also have really complicated relationship with hope. Mainly, I try not to hope as my body seems to be insanely problematic. I am disabled with multiple autoimmune diseases and genetic syndrome. While objectively I find the advancement in treatment interesting and amazing, I personally try not to hope. It is absolutely exhausting to get your hopes up only for the other shoe to drop.
Our immune systems are both one of the most fascinating things about us and for those with autoimmune issues like myself, the most annoying. Always good to see articles like this and I’m glad this focused on the actual science.
I’d love to sign up for the trial if they ever test it for vitiligo. There are wayyy more serious autoimmune issues that can and should be tested first for those truly suffering. Mine is just “hey look at weird color boy”.
Immune systems are wild, and it’s also wild how they can go spectacularly wrong in different ways. Autoimmune diseases run in families, but not necessarily the same disease. My great-aunt has Crohn’s. My dad and big brother both have segmental vitiligo (dad, just on the back of his neck and a shoulder, my brother on one arm), but my immune system decided my thyroid was the enemy. Like. Not fair, body. 🤣
My wife has MS. And even though we are of course far from being at a point where the disease will be cured, articles like this give hope.
There are a lot of smart people who are dealing with the topic. Hopefully they can get something solid done soon!
I will click on this headline when the link is to Nature or Scientific American or the Mayo Clinic. Thank you very much.
The article has the link to the original paper published in Nature Biomedical engineering at the bottom.
Thanks!
Hm, well the full paper is behind a subscription wall but the abstract sounds much more modest:
Our findings show that pGal–antigen therapy invokes mechanisms of immune tolerance to resolve antigen-specific inflammatory T-cell responses and suggest that the therapy may be applicable across autoimmune diseases.
“May be applicable” —> “can completely reverse” ???
